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This invention provides 1 a method of treating androgen- deprivation induced osteoporosis, bone fractures, loss of bone mineral density BMD, and or hot flashes in a male subject suffering from prostate cancer; 2 a method of preventing androgen- deprivation induced osteoporosis, bone fractures, loss of bone mineral density BMD, and or hot flashes in a male subject suffering from prostate cancer; 3 a method of suppressing or inhibiting androgen- deprivation induced osteoporosis, bone fractures, loss of bone mineral density BMD, and or hot flashes in a male subject suffering from prostate cancer; and 4 a method of reducing the risk of developing androgen- deprivation induced osteoporosis, bone fractures, loss of bone mineral density BMD, and or hot flashes in a male subject suffering from prostate cancer, by administering to the subject a pharmaceutical composition comprising cis- clomiphene or a pharmaceutically acceptable salt thereof <a href=https://clomid2buy.top/>clomid tab</a> 6 L h based on a population pharmacokinetic analysis